Cardiovascular disease risk in patients with inflammatory arthritis nowadays still substantially elevated
Authors' conclusion
CVD is currently still more prevalent in patients with IA compared with healthy controls and, more importantly, this elevated risk is highly influenced by an increased prevalence of 'traditional' CV risk factors.
Study context
- Population
- Consecutive patients with inflammatory arthritis (rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (SpA)) and controls2,050 inflammatory arthritis (IA) patients · 939 controls
- Participants
- 1,308 / 356 / 386 / 939
- Exposure
- RA, PsA and axial SpA vs controls
- RAn = 1,308
- PsAn = 356
- SpAn = 386
- Controlsn = 939reference
- Outcome
- Cardiovascular disease (CVD) (previous cardiovascular events, by questionnaire) vs controls
Methodological detailsconsecutive patients, logistic regression
- Consecutive patients
- Logistic regression
Main finding
As reported in the abstract
CVD, unadjusted
Each group vs controlsOdds ratio (95% CI)
RA
1.61(1.04–2.48)
PsA
2.12(1.23–3.66)
SpAtrend towards increased odds
1.43(0.79–2.59)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| CV risk adjusted for traditional risk factorsRAvs Controls | 0.95 (0.58–1.55) | |
| CV risk adjusted for traditional risk factorsPsAvs Controls | 1.19 (0.64–2.22) | |
| CV risk adjusted for traditional risk factorsSpAvs Controls | 0.91 (0.47–1.77) | |
| 0.512Odds ratio (log scale) |
Traditional cardiovascular (CV) risk factors
- Significantly elevated in IA vs controls
Original publication
Cardiovascular disease risk in patients with inflammatory arthritis nowadays still substantially elevated. RMD Open. Published 1 December 2023. doi:10.
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