Canadian Rheumatology Association/Canadian Research Group of Rheumatology in Immuno-Oncology Living Guidelines for Baseline Immunosuppression in Individuals With Preexisting Rheumatic Diseases Initiating Immune Checkpoint Inhibitors. Part 1: Preexisting Inflammatory Arthritides
Methodological detailssystematic literature review, GRADE approach, multidisciplinary panel
- Systematic literature review
- GRADE approach
- Multidisciplinary panel
Recommendations
As issued by the authors
- Best practice statements (8)
Shared decision making between patients and care team; careful consideration of risk of IA flare, risk of organ- or life-threatening manifestations, and potential effect of immunosuppression on cancer outcomes
Four specific recommendations, one each for preexisting RA, PMR, PsA and SpA, considering available evidence and expert consensus
General recommendation for preexisting inflammatory arthritides (IAs): reduce or stop baseline immunosuppression, unless there are extraarticular organ- or life-threatening manifestations
Original publication
Canadian Rheumatology Association/Canadian Research Group of Rheumatology in Immuno-Oncology Living Guidelines for Baseline Immunosuppression in Individuals With Preexisting Rheumatic Diseases Initiating Immune Checkpoint Inhibitors. Part 1: Preexisting Inflammatory Arthritides. J Rheumatol. Published 15 September 2025. doi:10.
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