Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review
Authors' conclusion
The findings suggested that patients generally preferred parenteral MTX formulations with attributes that facilitate self-administration.
Study context
- Population
- Adult rheumatoid arthritis (RA) patients using parenteral methotrexate (MTX), studies in English (Medline, Embase, Scopus, Cochrane Library, inception to May 2021)15 studies
- Outcome
- RA patients' perspectives on barriers and enablers in the use of parenteral MTX
Methodological detailsTheoretical Framework of Acceptability
- Theoretical Framework of Acceptability
Main finding
As reported in the abstract
- Constructs explored most: "affective attitude," "burden," "intervention coherence," "self-efficacy"; rarely "opportunity cost" and "perceived effectiveness"; not reported "ethicality"
- RA patients generally satisfied with MTX injections ("affective attitude")
- Barrier (burden): requirement for dexterity to administer MTX by injection
- Enabler (burden): lack of significant pain from MTX injection
Original publication
Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review. Arthritis Care Res (Hoboken). Published 12 June 2023. doi:10.
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