Associations between dietary index for gut microbiota and bone health outcomes
Authors' conclusion
In this nationally representative sample of U.S. adults, greater adherence to a dietary pattern characterized by microbiota-relevant components, as reflected by higher DI-GM scores, was associated with lower prevalence of fracture and osteoporosis, and modestly higher femoral neck BMD.
Study context
- Population
- Adults aged ≥ 20 years in National Health and Nutrition Examination Survey (NHANES) 2009–2020
- Participants
- 9,385 adults
- Exposure
- Per 1-unit increase in dietary index for gut microbiota
- Outcome
- Fracture
Methodological detailsmultivariable regression, nationally representative (NHANES 2009-2020)
- Multivariable regression
- Nationally representative (NHANES 2009-2020)
Main finding
As reported in the abstract
OR for fracture per 1-unit dietary index for gut microbiota (DI-GM) increase (95% CI 0.87-0.93); consistent across fracture sites and sexes
0.90
Observational data: associations, not effects.
Secondary outcomes
Osteoporosis, per 1-unit increase in DI-GM
- OR for osteoporosis per 1-unit DI-GM increase (95% CI 0.92-0.96); consistent across sexes
- 0.94
Femoral neck bone mineral density (BMD), per 1-unit increase in DI-GM
- β per 1-unit DI-GM increase, g/cm² (95% CI 0.001-0.005); particularly among men
- 0.003
Lumbar spine BMD, per 1-unit increase in DI-GM
- β per 1-unit DI-GM increase (95% CI −0.004 to 0.001); no association overall or in sex-stratified analyses
- −0.001
Original publication
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