Association of triglyceride-glucose-related indexes with mortality risk in RA: a prospective cohort study using the National Health and Nutrition Examination Survey (NHANES) database
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.60Authors' conclusion
This study highlights the prognostic value of TyG-related indicators with thresholds for predicting mortality
Study context
- Population
- RA participants from NHANES, 1999 to 2018
- Participants
- 764 participants
- Exposure
- Higher vs lower triglyceride-glucose (TyG)-related indexes
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsNHANES database, Kaplan-Meier curves, restricted cubic splines, multivariate Cox proportional hazards model
- NHANES database
- Kaplan-Meier curves
- Restricted cubic splines
- Multivariate Cox proportional hazards model
Main finding
All-cause mortality · median follow-up of 82 months
Hazard ratio
1.60
P = 0.011
As reported in the abstract
- All-cause deaths
- 235
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Cardiovascular mortality · median follow-up of 82 monthsMultivariate Cox | 2.36 | P = 0.017 |
- Cardiovascular mortality — Cardiovascular deaths
- 73
Non-linear association of cardiovascular mortality with TyG-WHtR, TyG-WC, TyG-BMI (restricted cubic splines (RCS))
- P for non-linearity
- < 0.05
- Inflection point TyG-WHtR
- 6.11
- Inflection point TyG-WC
- 869.84
- Inflection point TyG-BMI
- 314.01
Effect modification by BMI, drinking, race and education
- P for interaction
- < 0.05
Sensitivity analyses
- Supported positive associations between TyG-related indexes and mortality
Original publication
Association of triglyceride-glucose-related indexes with mortality risk in RA: a prospective cohort study using the NHANES database. Rheumatology (Oxford). Published 3 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →