Vasculitis & polymyalgia rheumatica
Association of the AAV-PRO questionnaire with established outcome measures in ANCA-associated vasculitis (AAV)
Authors' conclusion
Our data show convergent validity for all AAV-PRO subdomains, using the established questionnaires BDI and SF-36. The AAV-PRO domains scores were not correlated with clinician-derived instruments (including the BVAS and the VDI).
Study context
- Population
- Patients with AAV completing AAV-PRO, Beck's depression inventory (BDI), SF-36, BVAS and Vasculitis Damage Index (VDI) at baseline and after 3–6 months
- Participants
- 156 patients
- Outcome
- Association of AAV-PRO domains with disease activity and extent, damage, depression, health-related quality of life, and treatment
Methodological detailst-tests, correlation-based regression analyses
- T-tests
- Correlation-based regression analyses
Main finding
As reported in the abstract
Association of AAV-PRO domains with established measures
- Median AAV-PRO domain scores higher in patients reporting 'active disease' vs 'in remission'
- P < 0.001
- All AAV-PRO domain scores correlated strongly with BDI
- all r ≥ 0.319, all P ≤ 0.001
- All AAV-PRO domain scores correlated with all eight SF-36 subdomains
- all |r|≥0.267, all P ≤ 0.001
- AAV-PRO domains strongly predicted by BDI and SF-36 domains (strongest predictor of each domain)
- |β| ≥ 0.240
Observational data: associations, not effects.
Further findings
BVAS at enrolment, mean · baseline
- Mean BVAS at enrolment
- 1.4 ± 3.74
Longitudinal comparison (t1/t2) · 3-6 months
- No significant changes in the overall results
Original publication
Association of the AAV-PRO questionnaire with established outcome measures in AAV. Rheumatology (Oxford). Published 2 May 2023. doi:10.
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