Fibromyalgia & musculoskeletal pain
Association of fibromyalgia with cancerous and non-cancerous gastrointestinal comorbidities: a cross-sectional study
Authors' conclusion
Our findings suggest that FM is positively associated with various benign but not malignant GI disorders.
Study context
- Population
- Subjects with FM and age- and sex-matched controls, largest health maintenance organisation in Israel (mean age 56.5 years, SD=14; 91% female)
- Participants
- 18,598 vs 36,985
- Exposure
- FM vs age- and sex-matched controls
- Fibromyalgian = 18,598
- Controlsn = 36,985reference
- Outcome
- Association of FM with benign GI disorders (irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), celiac disease, Crohn's disease, ulcerative colitis) and GI malignancies (colorectal, pancreatic, stomach, liver, bile duct cancers)
Methodological detailsage- and sex-matched controls, electronic database of the largest health maintenance organisation in Israel
- Age- and sex-matched controls
- Electronic database of the largest health maintenance organisation in Israel
Main finding
As reported in the abstract
Each group vs controlsEstimate (95% CI)P value
Fibromyalgia
OR (IBS) 4.61(4.09–5.2)
P < 0.001Fibromyalgia
OR (GERD) 2.62(2.5–2.75)
P < 0.001Fibromyalgia
OR (PUD) 2.13(1.98–2.3)
P < 0.001Fibromyalgia
OR (celiac disease) 2.08(1.63–2.65)
P < 0.001Fibromyalgia
OR (Crohn's disease) 1.85(1.408–2.32)
P < 0.001Fibromyalgia
OR (ulcerative colitis) 1.81(1.4–2.33)
P < 0.001Observational data: associations, not effects.
Original publication
Association of fibromyalgia with cancerous and non-cancerous gastrointestinal comorbidities: a cross-sectional study. Clin Exp Rheumatol. Published 19 September 2022. doi:10.
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