Association of Chronic Kidney Disease With Increased Glucose Uptake–Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Patients With Gout
Authors' conclusion
Elevated glucose uptake-associated metabolic activity in both VAT and SAT was observed in patients with gout, which may contribute to CKD progression among patients with both gout and CKD.
Study context
- Population
- Patients who underwent positron emission tomography (PET)/CT scans, University of California San Diego patient database120 with gout
- Participants
- 221 patients
- Exposure
- Gout vs no gout
- Goutn = 120
- Outcome
- Mean VAT and SAT SUVmax on 18F-FDG PET/CT
Methodological detailsinverse probability of weighting adjustment, multivariable linear regression
- Inverse probability of weighting adjustment
- Multivariable linear regression
Main finding
As reported in the abstract
Mean VAT and SAT SUVmax (IPW-adjusted)
Β (mean visceral adipose tissue (VAT) SUVmax)
0.09
95% CI 0.04–0.15
Gout
Β (mean subcutaneous adipose tissue (SAT) SUVmax)
0.06
95% CI 0.01–0.12
Gout
Observational data: associations, not effects.
Further findings
Change in estimated glomerular filtration rate (eGFR) over 5 years after PET/CT per higher SUVmax, gout with chronic kidney disease (CKD) stage ≥3 (subgroup) · 5 years following PET/CT scans
- β, mean VAT SUVmax
- −1.76 (95% CI −3.50 to −0.01)
- β, mean SAT SUVmax
- −2.97 (95% CI −5.61 to −0.32)
Original publication
Association of Chronic Kidney Disease With Increased Glucose Uptake–Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Patients With Gout. Arthritis Care Res (Hoboken). Published 9 May 2025. doi:10.
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