Association between weight gain and knee osteoarthritis: a systematic review
Authors' conclusion
Weight gain in adults is associated with increased clinical and structural KOA and TKR.
Study context
- Population
- Participants with (or at risk of) knee OA23 studies
- Comparison
- Weight gain vs no weight gain
- Outcome
- Association between weight gain and knee OA: clinical features (pain, function, quality of life), structural progression and TKR
Methodological detailsROBINS-I risk of bias, meta-analyses where appropriate
- ROBINS-I risk of bias
- Meta-analyses where appropriate
Pooled result
As reported in the abstract
Knee OA clinical features, structural progression and TKR
- Significant detrimental effect of weight gain on pain
- 4 of 7 studies
- Significant detrimental effect on stiffness
- 2 of 2 studies
- Significant detrimental effect on function
- 5 of 6 studies
- Adverse effect on cartilage
- 6 of 9 studies
- Adverse effect on bone marrow lesions
- 1 of 4 studies
- Adverse effect on meniscal damage
- 1 of 3 studies
- Adverse effect on effusion/synovitis
- 1 of 1 study
- Weight gain significantly increased total knee replacement (TKR)
- 3 of 6 studies
- TKR per 5 kg weight gain in women (meta-analysis of 2 studies), HR
- 1.34 (1.18-1.51) (95% CI)
- TKR per 5 kg weight gain in men (meta-analysis of 2 studies), HR
- 1.25 (1.16-1.34) (95% CI)
Original publication
Association between weight gain and knee osteoarthritis: a systematic review. Osteoarthritis Cartilage. Published 26 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →