Association between sinusitis and incident rheumatic diseases: a population-based study
An erratum to this article was published (RMD Open, 14 May 2025 ↗)
Authors' conclusion
Preceding sinusitis is associated with increased incidence of rheumatic diseases
Study context
- Population
- Individuals meeting classification criteria for rheumatic diseases between 1995 and 2014 and matched controls (mean age 63, 67% women)matched case-control
- Participants
- 1,729 vs 5,187
- Comparison
- Antecedent sinusitis vs no sinusitis
- Casesn = 1,729
- Controlsn = 5,187reference
- Outcome
- Incident rheumatic diseases and disease groups by presence of sinusitis (diagnosis codes, PPV 96%)
Methodological detailspopulation-based, matched 3 controls per case on age, sex and length of prior electronic health record history, logistic regression, adjusted for confounders
- Population-based
- Matched 3 controls per case on age, sex and length of prior electronic health record history
- Logistic regression, adjusted for confounders
Main finding
As reported in the abstract
Incident rheumatic diseases associated with preceding sinusitis (adjusted)
Sinusitis vs No sinusitisOdds ratio (95% CI)
APS
7.0(1.8–27)
Sjögren's disease
2.4(1.1–5.3)
Vasculitis
1.4(1.1–1.9)
PMR
1.4(1.0–2.0)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Seronegative RA, acute sinusitisAcute sinusitisvs No sinusitis | 1.8 (1.1–3.1) | |
| Any rheumatic disease, sinusitis 5-10 years before onsetSinusitisvs No sinusitis | 1.7 (1.3–2.3) | |
| Rheumatic disease, seven or more sinusitis codes≥7 sinusitis codesvs No sinusitis | 1.7 (1.3–2.4) | |
| Incident rheumatic diseases in never smokers (subgroup)Sinusitisvs No sinusitis | 1.7 (1.3–2.2) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Association between sinusitis and incident rheumatic diseases: a population-based study. RMD Open. Published 22 February 2024. doi:10.
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