Association between physical activity and mortality in patients with osteoporosis: a cohort study of NHANES
Main finding · All-cause mortality in osteoporosis patientsResult — go to the resultHazard ratio 0.453 95% CI 0.268–0.767Authors' conclusion
Patients with osteoporosis need to engage in ≥ 300 min/week physical activity to significantly reduce their mortality risk. And the higher the volume of physical activity, the lower the risk of death.
Study context
- Population
- NHANES participants, including osteoporosis patients716 osteoporosis patients
- Participants
- 5,606 participants
- Exposure
- Physical activity volume categories vs inactive in osteoporotic patients
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsmultivariable Cox regression, restricted cubic spline analysis
- Multivariable Cox regression
- Restricted cubic spline analysis
Main finding
All-cause mortality in osteoporosis patients
Hazard ratio
0.453
95% CI 0.268–0.767
High activevs Inactive
HR 0.453 (95% CI 0.268–0.767)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Cardiovascular mortality in osteoporosis patientsHigh activevs Inactive | 0.521 (0.259–1.049) | |
| 0.20.5125Hazard ratio (log scale) |
Interaction by age, sex and BMI
- No significant interactions
- P for interaction > 0.05
Dose-response, PA volume and all-cause mortality in osteoporosis (restricted cubic spline)
- Linear relationship, overall
- P < 0.01 [overall]
- Non-linearity
- P = 0.470 [non-linearity]
- Non-linear in participants without osteoporosis
Dose-response, PA volume and cardiovascular mortality in osteoporosis (restricted cubic spline)
- Linear relationship, overall
- P = 0.003 [overall]
- Non-linearity
- P = 0.610 [non-linearity]
- Non-linear in participants without osteoporosis
Sensitivity analysis / adjustment for vigorous PA proportion
- Only the high active group still showed a significant reduction in mortality
Original publication
Association between physical activity and mortality in patients with osteoporosis: a cohort study of NHANES. Osteoporos Int. Published 10 October 2024. doi:10.
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