Association between knee magnetic resonance imaging markers and knee symptoms over 6–9 years in young adults
Authors' conclusion
BMLs and cartilage defects were positively associated with knee symptoms, whereas cartilage volume and thickness at MFTC and total bone area were weakly and negatively associated with knee symptoms.
Study context
- Population
- Young adults in the Childhood Determinants of Adult Health Knee Cartilage study (CDAH-knee; 2008–2010), followed up 6–9 years later (CDAH-3; 2014–2019)
- Outcome
- Knee symptoms (WOMAC) in association with baseline knee MRI markers
- Follow-up
- Baseline and 6-9 years
Methodological detailsunivariable and multivariable (age, sex, BMI adjusted) zero-inflated Poisson regression, Mean age 34.95 (s.d. 2.72) and 43.27 (s.d. 3.28) years at CDAH-knee and CDAH-3; 49% and 48% females
- Univariable and multivariable (age, sex, BMI adjusted) zero-inflated Poisson regression
- Mean age 34.95 (s.d. 2.72) and 43.27 (s.d. 3.28) years at CDAH-knee and CDAH-3; 49% and 48% females
Main finding
As reported in the abstract
Knee symptoms (WOMAC), cross-sectional at baseline
- Medial femorotibial compartment (MFTC) cartilage volume, ratio of the mean (RoM) 0.99971084 (95% CI 0.9995525, 0.99986921)
- P < 0.001
- Lateral femorotibial compartment (LFTC) cartilage volume, RoM 0.99982602 (95% CI 0.99969915, 0.9999529)
- P = 0.007
- Patellar cartilage volume, RoM 0.99981722 (95% CI 0.99965326, 0.9999811)
- P = 0.029
- Total bone area, RoM 0.9210485 (95% CI 0.8939677, 0.9489496)
- P < 0.001
Observational data: associations, not effects.
Further findings
Knee symptoms (WOMAC) after 6-9 years
- Patellar cartilage volume, RoM 0.99975523 (95% CI 0.99961427, 0.99989621)
- P = 0.014
- MFTC cartilage thickness, RoM 0.72090775 (95% CI 0.59481806, 0.87372596)
- P = 0.001
- Total bone area, RoM 0.9588811 (95% CI 0.9313379, 0.9872388)
- P = 0.005
- Cartilage defects and bone marrow lesions (BMLs) associated with greater knee symptoms
Original publication
Association between knee magnetic resonance imaging markers and knee symptoms over 6–9 years in young adults. Rheumatology (Oxford). Published 18 May 2023. doi:10.
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