Lupus & antiphospholipid syndrome
Assessment of myocardial dysfunction of patients with systemic lupus erythematosus based on myocardial perfusion imaging and analysis of potential influencing factors
Main finding · Incidence of myocardial dysfunctionResult — go to the resultχ2 16.131Authors' conclusion
Positive anti-SSA/Ro52kDa antibody was an independent risk factor for myocardial dysfunction in SLE patients.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) evaluated by 99mTc-MIBI rest gated myocardial perfusion imaging (rGMPI)
- Participants
- 76 vs 46
- Comparison
- SLE vs controls without autoimmune or other inflammatory diseases
- SLEn = 76
- Controlsn = 46reference
- Outcome
- Myocardial dysfunction on 99mTc-MIBI rGMPI
Main finding
Incidence of myocardial dysfunction
χ2
16.131
P < 0.001
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Positive anti-SSA/Ro52kDa antibody, independent correlation with myocardial dysfunction in SLE
| OR (95% CI) | P value | ||
|---|---|---|---|
| Positive anti-SSA/Ro52kDa antibody | 3.159 (1.071–9.316) | P = 0.037 | |
| 0.10.31310Odds ratio (log scale) |
Factors associated with impaired myocardial function in SLE
- Moderate/severe disease activity, OR (p = .049)
- 2.753
- Decreased myocardial perfusion, OR (p = 0.015)
- 5.359
- Positive anti-SSA/Ro52kDa antibody, OR (p = 0.014)
- 3.646
Original publication
Assessment of myocardial dysfunction of patients with systemic lupus erythematosus based on myocardial perfusion imaging and analysis of potential influencing factors. Lupus. Published 14 April 2025. doi:10.
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