Antibiotics in inflammatory arthritis and background population one year before and after diagnosis: a nationwide drug utilization study
Authors' conclusion
Antibiotics are more frequently dispensed to individuals developing IA compared with the BP. Antibiotic utilization patterns change after IA diagnosis with marked differences among IA subgroups.
Study context
- Population
- Danish adults with a first-time diagnosis of RA, PsA or AS/SpA, 2010 through 2018, and matched background population28,504 inflammatory arthritis (IA) patients
- Participants
- 16,130 / 5,988 / 6,386 / 285,040
- Exposure
- Patients with new-onset inflammatory arthritis (RA, PsA, AS/SpA) vs matched background population
- RAn = 16,130
- PsAn = 5,988
- AS/SpAn = 6,386
- Background population (BP)n = 285,040reference
- Outcome
- Prevalence of any antibiotic dispensing and total antibiotic dispensing
- Follow-up
- Year before and after diagnosis
Methodological detailsregistry-based, matched on sex and birthdate (1:10)
- Registry-based
- Matched on sex and birthdate (1:10)
Main finding
As reported in the abstract
Total dispensed antibiotics within one year before diagnosis vs BP
PRR
1.48
CI 1.46–1.51
RA
PRR
1.67
CI 1.62–1.72
PsA
PRR
1.52
CI 1.47–1.56
AS/SpA
- Amount increased in IA patients three months before diagnosis vs preceding three-month period
- 22%
Observational data: associations, not effects.
Further findings
| Outcome | PRR (CI) |
|---|---|
| Total one-year antibiotic dispensing, after vs before diagnosisRA after diagnosis vs RA before diagnosis · remained constant | 0.99 (0.97–1.01) |
| Total one-year antibiotic dispensing, after vs before diagnosisPsA after diagnosis vs PsA before diagnosis · decreased | 0.91 (0.87–0.94) |
| Total one-year antibiotic dispensing, after vs before diagnosisAS/SpA after diagnosis vs AS/SpA before diagnosis · increased | 1.08 (1.04–1.12) |
Prevalence of any antibiotic dispensing in IA patients after diagnosis (decreased) · 1 year after diagnosis
- IA, prevalence of any antibiotic dispensing
- 40.6%
Original publication
Antibiotics in inflammatory arthritis and background population one year before and after diagnosis: a nationwide drug utilization study. Rheumatology (Oxford). Published 27 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →