Anti-HMGCR myopathy: observed ethnic differences in disease and disease outcomes in New Zealand
Authors' conclusion
In addition to having higher incidence of anti-HMGCR myopathy, Polynesians are affected at a younger age and are less likely to achieve normal CK levels despite treatment over similar follow-up periods.
Study context
- Population
- Patients with anti-HMGCR myopathy (anti-HMGCR positive by immunoprecipitation assay), New Zealand91 identified
- Participants
- 91 patients
- Exposure
- Polynesian vs New Zealand (NZ) European patients with anti-HMGCR myopathy
- Polynesiann = 35
- NZ Europeann = 48reference
- Outcome
- Ethnic differences in disease phenotype, treatment and outcome
Methodological detailsclinical record review, prioritized ethnicity data
- Clinical record review
- Prioritized ethnicity data
Main finding
As reported in the abstract
Age at presentation
P = 0.009
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CK normalisation over follow-upEven after controlling for length of follow-up | P = 0.016 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Anti-HMGCR myopathy: observed ethnic differences in disease and disease outcomes in New Zealand. Rheumatology (Oxford). Published 14 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →