Vasculitis & polymyalgia rheumatica
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in patients with rheumatoid arthritis: A single-center cohort study
Authors' conclusion
RA often preceded the diagnosis of AAV and GPA was the most frequently observed AAV.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and positive ANCA, single centre
- Participants
- 77 patients
- Exposure
- RA+AAV vs RA+ANCA
- Outcome
- Characteristics of AAV in patients with RA and positive ANCA; factors associated with AAV
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AAV characteristics in RA+ANCA
- AAV diagnosed
- 29 %
- Granulomatosis with polyangiitis (GPA) among AAV
- 45 %
- MPA among AAV
- 36 %
- EGPA among AAV
- 5 %
- Unclassifiable AAV
- 14 %
- Renal involvement
- 41 %
- Upper airway involvement
- 36 %
- RA diagnosis preceded AAV
- 59 %
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Factors more frequent in RA+AAV than RA+ANCA | P < 0.05 |
- Factors more frequent in RA+AAV than RA+ANCA: positive RF, MPO-ANCA, rheumatoid nodules, inflammatory eye disease; positive ANCA via immunofluorescence alone and positive dsDNA
Cohort ANCA profile
%
- p-ANCA positivity
- 45
- Myeloperoxidase (MPO) positivity
- 42
Treatment exposure for RA
- Did not differ between the two groups
Original publication
ANCA-associated vasculitis in patients with rheumatoid arthritis: A single-center cohort study. Semin Arthritis Rheum. Published 28 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →