Age- and dose-dependent effect of statin use on the risk of osteoporotic fracture in older adults
Main finding · Major osteoporotic fracturesResult — go to the resultAdjusted hazard ratio 0.77 95% CI 0.72–0.83Authors' conclusion
Our results showed that statin use was associated with significant reduction in the risk of osteoporotic fractures in general older population.
Study context
- Population
- Older adults without previous history of osteoporosis, Korean National Health Insurance Service-Senior cohort database, observed until December 31 201254,959 osteoporotic fractures
- Participants
- 365,656 adults
- Exposure
- Statin use vs non-use
- Outcome
- Major osteoporotic fractures
Methodological detailsnational health insurance database cohort, weighted Cox proportional hazards model, inverse-probability of treatment weighting
- National health insurance database cohort
- Weighted Cox proportional hazards model
- Inverse-probability of treatment weighting
Main finding
As reported in the abstract
6.27 years of follow-up
Adjusted hazard ratio
0.77
95% CI 0.72–0.83
P < 0.001
Statin usersvs Non-users
adjusted HR 0.77 (95% CI 0.72–0.83); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Hip fractures | adjusted HR 0.49 (95% CI 0.38–0.62) | P < 0.001 | |
| Vertebral fractures | adjusted HR 0.70 (95% CI 0.64–0.77) | P < 0.001 | |
| Osteoporotic fracture by cumulative statin dose (cDDD)30-364 cDDDvs Non-users | HR 0.97 (95% CI 0.91–1.02) | ||
| Osteoporotic fracture by cumulative statin dose (cDDD)365-1,094 cDDDvs Non-users | HR 0.45 (95% CI 0.40–0.51) | ||
| Osteoporotic fracture by cumulative statin dose (cDDD)≥ 1,095 cDDDvs Non-users | HR 0.22 (95% CI 0.15–0.33) | ||
| 0.10.31310Ratio (log scale) |
- Vertebral fractures: majority of fractures (69.5%) were vertebral fractures
By sex
- Results broadly comparable in patterns of risk reduction by statin use
By age at statin initiation
- Statin initiated at age ≥ 80 years had the highest risk reduction for most outcomes vs non-users
Original publication
Age- and dose-dependent effect of statin use on the risk of osteoporotic fracture in older adults. Osteoporos Int. Published 8 August 2023. doi:10.
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