Adherence to secondary fracture prevention is associated with reduced risk of subsequent fractures
Authors' conclusion
These results confirm that patients who were able and willing to attend FLS had lower risk of subsequent fractures and mortality than non-attenders.
Study context
- Population
- Women and men ≥ 50 years with an index fracture of any type during 2015–2018, Norway
- Participants
- 1,041 / 895 / 427 / 174
- Exposure
- Fracture liaison services (FLS) attenders vs non-attenders; Anti-osteoporotic drugs (AOD)-adherent vs non-adherent patients
- Attendersn = 1,041
- Non-attendersn = 895reference
- Adherentn = 427
- Non-adherentn = 174reference
- Outcome
- Subsequent fractures and mortality
Methodological detailssingle-centre, sub-study of the Norwegian Capture the Fracture Initiative, adjusted for age, sex, BMI, smoking, prior fracture and index hip fracture
- Single-centre
- Sub-study of the Norwegian Capture the Fracture Initiative
- Adjusted for age, sex, BMI, smoking, prior fracture and index hip fracture
Main finding
As reported in the abstract
Subsequent fractures of any type · median 3.5-years observation (range 0.5 to 6.3)
Hazard ratio (95% CI)
Attendersvs Non-attenders
0.80(0.64–0.999)
Adherentvs Non-adherent
0.51(0.35–0.72)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality · median 3.5-years observation (range 0.5 to 6.3)Attendersvs Non-attenders | 0.67 (0.51–0.89) | |
| 0.512Hazard ratio (log scale) |
Mortality · median 3.5-years observation (range 0.5 to 6.3)
- Adherent vs non-adherent to AOD: no difference in mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Adherence to secondary fracture prevention is associated with reduced risk of subsequent fractures. Osteoporos Int. Published 24 September 2025. doi:10.
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