A validation of register-derived diagnoses of interstitial lung disease in patients with inflammatory arthritis: data from the NOR-DMARD study
Authors' conclusion
The validity of register-based diagnoses of ILD must be carefully considered in epidemiological studies.
Study context
- Population
- Patients with RA, PsA or SpA starting DMARD treatment in NOR-DMARD, linked to the Norwegian Patient Registry and Cause of Death Registrycases with an interstitial lung disease (ILD) diagnosis
- Participants
- 71 patients
- Comparison
- Register-derived ILD diagnoses (ICD-10 J84 or J99) vs chest computed tomography (CT) and medical records as gold standard
- Register-derived ILD diagnosisn = 71
- Outcome
- PPV of register-derived ILD diagnosis, verified by chest CT and medical records
Methodological detailsvalidation study, register linkage, multicentre prospective observational register, Two expert thoracic radiologists scored CT examinations; medical records searched for multidisciplinary justification
- Validation study
- Register linkage
- Multicentre prospective observational register
- Two expert thoracic radiologists scored CT examinations; medical records searched for multidisciplinary justification
Performance
As reported in the abstract
PPV of register-derived ILD diagnosis (vs CT and medical records)
| Test or model | PPV |
|---|---|
| Register-derived ILD diagnosis | 54.9% |
Register-derived ILD diagnosis
PPV54.9%
- Verified cases
- 39/71
Further findings
- PPV in subset with ILD code at two or more time-points and CT in relevant period
- 72.2% · PPV
ILD confirmed on CT (CT available in 65/71, 91.5%)
- ILD confirmed on CT
- 29/65 (44.6%)
- Further confirmed by medical records
- 10
Original publication
A validation of register-derived diagnoses of interstitial lung disease in patients with inflammatory arthritis: data from the NOR-DMARD study. Scand J Rheumatol. Published 5 February 2024. doi:10.
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