Systemic sclerosis & Raynaud's
A screening tool to detect interstitial lung disease in systemic sclerosis: the ILD-RISC score
Authors' conclusion
The ILD-RISC score was developed and validated to predict the presence of SSc-ILD.
Study context
- Population
- Patients with SSc screened for SSc-ILD on high-resolution CTderivation cohort
- Participants
- 533 patients
- Outcome
- Presence of SSc-ILD on high-resolution CT
Methodological detailsderivation cohort, separate cross-sectional validation cohort, longitudinal application in cohort with negative baseline high-resolution computed tomography (HRCT), multivariable logistic regression with backward selection, nominal group technique for item selection
- Derivation cohort
- Separate cross-sectional validation cohort
- Longitudinal application in cohort with negative baseline HRCT
- Multivariable logistic regression with backward selection
- Nominal group technique for item selection
Performance
As reported in the abstract
Presence of SSc-ILD on high-resolution CT (derivation cohort)
| Test or model | AUC (score) | Sensitivity | Specificity |
|---|---|---|---|
| ILD-RISC score ≥0.3 | 79.1% (75.3-83.0%) | 85.6% | 53.6% |
ILD-RISC score ≥0.3
AUC (score)79.1% (75.3-83.0%)
Sensitivity85.6%
Specificity53.6%
Further findings
Validation cohort (247 patients)
- Sensitivity and specificity of ILD-RISC score ≥0.3 confirmed in validation cohort
Longitudinal application in patients with negative baseline HRCT (n = 819)
- Developed SSc-ILD
- 170
- Follow-up visits with low ILD-RISC score
- almost 50%
Original publication
A screening tool to detect interstitial lung disease in systemic sclerosis: the ILD-RISC score. Rheumatology (Oxford). Published 14 August 2025. doi:10.
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