A prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA
Authors' conclusion
Serum klotho levels had a U-shaped correlation with all-cause mortality in patients with RA
Study context
- Population
- Adults with rheumatoid arthritis (RA) from National Health and Nutrition Examination Survey (NHANES) 2007–2016, USA
- Participants
- 841 adults
- Exposure
- Serum klotho quartiles Q2–Q4 vs Q1
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsNHANES 2007–2016, Cox regression, Kaplan-Meier curves, restricted cubic spline models
- NHANES 2007–2016
- Cox regression
- Kaplan-Meier curves
- Restricted cubic spline models
Main finding
As reported in the abstract
All-cause mortality risk increased with decreasing serum klotho below threshold
838.81 pg/mL
Observational data: associations, not effects.
Further findings
Subgroups
- Protective effect of klotho more pronounced in male, white ethnicity, age ≥ 60 years, BMI < 25 kg/m², eGFR ≥ 60 mL/ (min × 1.73 m²), and 25-hydroxyvitamin D ≥ 50 nmol/L
Original publication
A prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA. Arthritis Res Ther. Published 16 August 2023. doi:10.
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