A longitudinal study using B mode ultrasound and power Doppler as monitoring imaging tools in inclusion body myositis
Authors' conclusion
Certain US domains, such as FT, showed measurable changes over time and correlated with disease progression.
Study context
- Population
- Participants with IBM (60% male, median age 70; 85.7% not on immunosuppression)21 (60%) males
- Participants
- 35 participants
- Exposure
- Progressors vs non-progressors; changes in B mode ultrasound (US) and power Doppler (PD) over time
- Outcome
- Ability of B mode US and PD (FT, muscle bulk, echogenicity, PD of deltoid and vastus lateralis (VL)) to detect changes over time and correlation with disease progression
- Follow-up
- Median 26 months
Methodological detailsfour visits, median follow-up 26 months
- Four visits
- Median follow-up 26 months
Main finding
As reported in the abstract
Progressors
0.06
Non-progressors
0.09
P = 0.017
- Only FT-deltoid increased significantly over time with follow-up
- P < 0.001
Observational data: associations, not effects.
Further findings
Sex differences at baseline
- Males had lower FT-VL than females
- P = 0.018
- Males had higher muscle bulk than females
- P = 0.002
Original publication
A longitudinal study using B mode ultrasound and power Doppler as monitoring imaging tools in inclusion body myositis. Clin Exp Rheumatol. Published 1 July 2023. doi:10.
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