A comparative study on the clinical and magnetic resonance imaging features between seronegative and seropositive rheumatoid arthritis
Authors' conclusion
SNRA had more severe inflammation but milder erosion compared with SPRA.
Study context
- Population
- Newly diagnosed RA patients with hand magnetic resonance imaging (MRI) data at baseline
- Participants
- 310 participants
- Exposure
- Seronegative RA vs seropositive RA
- Outcome
- Clinical and MRI features of SNRA vs SPRA, and factors associated with structural damage (erosion rate)
Methodological detailscomparative, 12-month follow-up, multivariate analysis
- Comparative
- 12-month follow-up
- Multivariate analysis
Main finding
As reported in the abstract
baseline
- Seronegative rheumatoid arthritis (SNRA) had a higher incidence of low BMD
- p=0.009
- SNRA had a lower erosion score
- p<0.001
- SNRA had a lower probability of interstitial lung disease (ILD)
- p=0.019
Observational data: associations, not effects.
Further findings
Factors associated with erosion rate in SNRA (multivariate analysis)
- Synovitis score, IL-6 and TNF-α levels, and hyperglobulinaemia positively associated with erosion rate (p-values were all <0.05)
Treatment response · 12-month follow-up
- Comparable between the two groups (p-values were all >0.05)
Original publication
A comparative study on the clinical and magnetic resonance imaging features between seronegative and seropositive rheumatoid arthritis. Clin Exp Rheumatol. Published 6 April 2023. doi:10.
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