Lupus & antiphospholipid syndrome
A 6-year prospective study on work participation and the associated factors in Dutch patients with systemic lupus erythematosus (SLE)
Authors' conclusion
This study shows that alongside demographic and disease-related characteristics, also work characteristics are associated with having and maintaining paid work in SLE patients.
Study context
- Population
- Patients diagnosed with SLE, independent of disease duration, under treatment in Amsterdam UMC location VUmc or Reade (Amsterdam SLE cohort, 2007–2018)157 at six years
- Participants
- 220 patients
- Outcome
- Having and maintaining paid work for ≥ 5 years
- Follow-up
- Six-year period
Methodological detailslongitudinal, 6-year follow-up, Generalized Estimating Equations with logit link function, logistic regression
- Longitudinal
- 6-year follow-up
- Generalized Estimating Equations with logit link function
- Logistic regression
Main finding
As reported in the abstract
Paid employment
- Employed at baseline
- 52% (114/220)
- Employed after six years
- 46% (73/157)
- Unemployed at baseline who gained work during follow-up
- 16% (17/106)
- Of those gaining work, also maintained work
- 47% (8/17)
- Employed at baseline who remained employed throughout six-year follow-up
- 29% (33/114)
Observational data: associations, not effects.
Further findings
Main reported reason for unemployment: SLE-related symptoms
- SLE-related symptoms
- 63%
Work disability at baseline
- Longer disease duration associated with work disability
Original publication
A 6-year prospective study on work participation and the associated factors in Dutch patients with systemic lupus erythematosus (SLE). Arthritis Res Ther. Published 2 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →