CurrentRheuma — Osteoarthritis

BMI and Varus Malalignment Compound to Define a High-Risk Phenotype for Compartment-Specific Knee Osteoarthritis Progression

2026-11-13T05:15:37.279Z

Cohort study · Osteoarthritis Cartilage, 2026.

Retatrutide Once Weekly in Adults with Knee Osteoarthritis Pain and Obesity

2026-11-09T17:15:24.911Z

Research article · N Engl J Med, 2026.

Depth-specific characterization of bone microarchitecture in the femoral head: implications for osteoarthritis and osteoporosis research

2026-11-05T16:08:02.128Z

Research article · Arthritis Res Ther, 2026.

Spatial architecture of the synovium identifies clinically relevant phenotypes of osteoarthritis

2026-11-05T16:08:02.128Z

Research article · Osteoarthritis Cartilage, 2026.

Artificial Intelligence‐Driven Extraction of Patient‐Reported Pain Outcomes in Osteoarthritis Using Large Language Models

2026-11-05T13:24:18.717Z

Diagnostic or prognostic study · Arthritis Care Res (Hoboken), 2026.

Longitudinal remodeling of acylcarnitine signatures before and after arthroplasty for osteoarthritis: A 7-year cohort study

2026-11-05T13:24:18.717Z

Cohort study · Osteoarthritis Cartilage, 2026.

Sarcopenic obesity and pain sensitivity, central sensitization–related symptoms, and physical function among patients undergoing total knee arthroplasty: A cross-sectional study

2026-11-05T13:24:18.717Z

Cross-sectional study · Osteoarthritis Cartilage, 2026.

Serum urate and the risk of incident osteoarthritis: A prospective cohort study

2026-11-05T13:24:18.717Z

Cohort study · Osteoarthritis Cartilage, 2026.

Spatial Proteomics Identifies Distinct Synovial Microenvironments in Hip and Knee Osteoarthritis

2026-11-05T13:24:18.717Z

Research article · Arthritis Rheumatol, 2026.

Comparative risks of mortality and fractures in patients with osteoarthritis initiating tramadol versus other opioids

2026-11-05T13:10:58.883Z

Cohort study · Arthritis Rheumatol, 2026.

Development of a Composite Pain Sensitivity Index and Its Relationships with Knee Pain Severity and Patterns in People with or at Risk for Knee Osteoarthritis: The Multicenter Osteoarthritis Study

2026-11-05T13:10:58.883Z

Cohort study · Osteoarthritis Cartilage, 2026.

Efficacy and safety of the TRPV1 agonist RTX-GRT7039 in patients with pain associated with knee osteoarthritis: Results from a phase 3, randomised, placebo-controlled trial

2026-11-05T13:10:58.883Z

Randomized controlled trial · Osteoarthritis Cartilage, 2026.

High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis : A Randomized Controlled Multicenter Trial

2026-11-04T23:59:25.899Z

Randomized controlled trial · Ann Intern Med, 2023. KOOS scores, end of the intervention (3 months): Both groups improved over time, but there were no benefits of high-dose therapy in most comparisons

Development of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a Sulfonylurea

2026-11-04T23:58:57.553Z

Cohort study · JAMA Netw Open, 2023. Incident OA — Metformin vs Sulfonylurea: aHR 0.76 (95% CI 0.68-0.85); P < .001; risk reduced by 24%

3D patellar shape is associated with radiological and clinical signs of patellofemoral osteoarthritis

2026-11-04T23:52:55.048Z

Cross-sectional study · Osteoarthritis Cartilage, 2023. Association of SSM shape variants with group status: Shape variants with a statistically significant (<0.05) association with group status 4

A sex- and site-specific relationship between body mass index and osteoarthritis: evidence from observational and genetic analyses

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2023. Diagnosed OA per 5 kg/m2 increment in BMI (observational): HR for diagnosed OA per 5 kg/m2 BMI increment 1.38 (95% CI 1.37-1.39)

Acute loading has minor influence on human articular cartilage gene expression and glycosaminoglycan composition in late-stage knee osteoarthritis: a randomised controlled trial

2026-11-04T23:52:55.048Z

Randomized controlled trial · Osteoarthritis Cartilage, 2023. Exercise vs No loading: chondroitin sulphate extractability (increased with exercise) not reported; 95% CI 1.01 to 2.46; P = 0.0486

Association between weight gain and knee osteoarthritis: a systematic review

2026-11-04T23:52:55.048Z

Meta-analysis · Osteoarthritis Cartilage, 2022. Knee OA clinical features, structural progression and TKR: Significant detrimental effect of weight gain on pain 4 of 7 studies

Association of physical activity with loss of knee joint space width over two years: a compositional data analysis in the Osteoarthritis Initiative

2026-11-04T23:52:55.048Z

Secondary analysis · Osteoarthritis Cartilage, 2023. Association of PA composition with medial JSW loss (adjusted regression), 2 years: Higher MVPA, β -0.0005, P = 0.97

Bariatric surgery, osteoarthritis and arthroplasty of the hip and knee in Swedish Obese Subjects – up to 31 years follow-up of a controlled intervention study

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2023. Hip OA, incidence rate: Surgery IR 5.3 (95% CI 4.7-6.1) · Controls IR 6.6 (95% CI 5.9-7.5)

Changes in physical activity and the association between pain and physical activity – a longitudinal analysis of 17,454 patients with knee or hip osteoarthritis from the GLA:D® registry

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2022. Reached or maintained at least moderate physical activity level at follow-ups: Low activity 37% · All 69%

Changes to consultations and diagnosis of osteoarthritis in primary care during the COVID-19 pandemic

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2023. Relative reduction in GP consultations, 2020 vs 5-year average, peak of the first wave: All musculoskeletal consultations, first wave peak 46.7% (95% CI: 43.9-49.3%)

Circulating miRNAs in hand osteoarthritis

2026-11-04T23:52:55.048Z

Case-control study · Osteoarthritis Cartilage, 2022. Circulating plasma miRNAs, hand OA vs healthy controls: miRNAs different between hand OA and healthy controls in screening cohort (of 754) 40

Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis

2026-11-04T23:52:55.048Z

Research article · Osteoarthritis Cartilage, 2022. Costs and QALYs — TG vs UC-GS: cost increase 689 $; QALY reduction of 0.012

Effects and mechanotransduction pathways of therapeutic ultrasound on healthy and osteoarthritic chondrocytes: a systematic review of in vitro studies

2026-11-04T23:52:55.048Z

Meta-analysis · Osteoarthritis Cartilage, 2022. Regardless of setup, ultrasound stimulated cartilage production and suppressed its degradation, although the effect size was nonsignificant

Evaluating Osteoarthritis Management Programs: outcome domain recommendations from the OARSI Joint Effort Initiative

2026-11-04T23:52:55.048Z

Guideline or statement · Osteoarthritis Cartilage, 2023. Domains meeting criteria for recommendation: Core domain: "ability to participate in daily activities" (only one) 1

Exercise and education vs intra-articular saline for knee osteoarthritis: a 1-year follow-up of a randomized trial

2026-11-04T23:52:55.048Z

Secondary analysis · Osteoarthritis Cartilage, 2023. KOOS pain, mean change from baseline, 1 year: GLAD mean 8.4 · OLP mean 7.0

Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD)

2026-11-04T23:52:55.048Z

Meta-analysis · Osteoarthritis Cartilage, 2022. Pooled standardised PASS (0–100): Pooled standardised PASS 27 (95% CI: 21 to 35)

Improved responsiveness to change in joint space width over 24-month follow-up: comparison of 3D JSW on weight-bearing CT vs 2D JSW on radiographs in the MOST study

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2022. Responsiveness (SRM) of JSWx change, medial tibiofemoral compartment, 24 months: 3D JSWx: SRM range -0.18, -0.24 · 2D JSWx: SRM range -0.10, -0.16

Instruments to assess appropriateness of hip and knee arthroplasty: a systematic review

2026-11-04T23:52:55.048Z

Meta-analysis · Osteoarthritis Cartilage, 2023. Hawker et al. JA consensus criteria met by instruments: Instruments meeting all Hawker et al. criteria 0

The KNee OsteoArthritis Prediction (KNOAP2020) challenge: An image analysis challenge to predict incident symptomatic radiographic knee osteoarthritis from MRI and X-ray images

2026-11-04T23:52:55.048Z

Diagnostic or prognostic study · Osteoarthritis Cartilage, 2022. Model performance, 78 months: Highest ROCAUC model: ROCAUC 0.64 (95% CI: 0.57-0.70) · Highest BACC model: BACC 0.59 (95% CI: 0.52-0.65)

Metabolic syndrome and the progression of knee osteoarthritis on MRI

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2023. Association of baseline MetS severity with progression of MRI features, 5 years: MetS severity associated with progression of osteophytes in all compartments

MRI underestimates presence and size of knee osteophytes using CT as a reference standard

2026-11-04T23:52:55.048Z

Diagnostic or prognostic study · Osteoarthritis Cartilage, 2023. Osteophytes detected by MRI among CT-defined osteophytes, by compartment, baseline: PFJ: MRI detected 141 (72%) of 197 CT-defined OPs; w-kappa 0.58 (0.52-0.65) (95% CI)

Potential surrogate outcomes in individuals at high risk for incident knee osteoarthritis

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2023. Potential surrogate outcomes over 2.5 years associated with incident clinical knee OA, 6.5 years: Most pre-defined potential surrogate outcomes showed ≥10% change in the population over 2.5 years

Prediction of knee pain improvement over two years for knee osteoarthritis using a dynamic nomogram based on MRI-derived radiomics: a proof-of-concept study

2026-11-04T23:52:55.048Z

Diagnostic or prognostic study · Osteoarthritis Cartilage, 2022. Nomogram discrimination (AUC) for knee pain improvement: Training: AUC 0.79 (95% CI: 0.72-0.79) · Validation: AUC 0.83 (95% CI: 0.70-0.96)

Recommendations for the delivery of therapeutic exercise for people with knee and/or hip osteoarthritis. An international consensus study from the OARSI Rehabilitation Discussion Group

2026-11-04T23:52:55.048Z

Guideline or statement · Osteoarthritis Cartilage, 2022.

Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study

2026-11-04T23:52:55.048Z

Cross-sectional study · Osteoarthritis Cartilage, 2023. Pain sensitization and physical function: Lower PPTs and presence of TS associated with worse WOMAC-F scores, slower walking speeds and weaker knee extension

Serum carboxymethyllysine concentration is associated with erosive hand osteoarthritis

2026-11-04T23:52:55.048Z

Cross-sectional study · Osteoarthritis Cartilage, 2023. Serum CML concentration: Erosive HOA median 178.7 (IQR 157.1-208.8) μmol/mol Lys · Non-erosive HOA median 194.7 (IQR 168.9-217.1) μmol/mol Lys

Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2022. Cartilage thickness loss, entire femorotibial joint, 24 months: Test-retest precision, entire femorotibial joint (μm) 69

Trajectories of body mass index from early adulthood to late midlife and incidence of total knee arthroplasty for osteoarthritis: findings from a prospective cohort study

2026-11-04T23:52:55.048Z

Cohort study · Osteoarthritis Cartilage, 2022. TKA for OA, Over 12.4 years — TR2 vs TR1: HR 2.03 (95% CI 1.64-2.52)

Uncovering the “riddle of femininity” in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment

2026-11-04T23:52:55.048Z

Meta-analysis · Osteoarthritis Cartilage, 2023. Cartilage outcomes, post-menopausal vs non-menopausal animals (effect size; + greater in menopause, − greater in non-menopause) — Post-menopausal vs Non-menopausal: Effect size, cartilage histological scoring not reported; 95% CI 0.75, 1.72

Who are likely to benefit from the Good Life with osteoArthritis in Denmark (GLAD) exercise and education program? An effect modifier analysis of a randomised controlled trial

2026-11-04T23:52:55.048Z

Secondary analysis · Osteoarthritis Cartilage, 2022. KOOS pain change, subgroup contrasts (GLAD vs OLP), week 9 — GLAD vs OLP: subgroup contrast (baseline analgesic use) 10.3 KOOS pain points (95% CI 3.0 to 17.6); participants using analgesics at baseline

Making the current non-surgical treatments for knee osteoarthritis more effective: Solutions from a diverse patient group

2026-11-04T23:42:37.367Z

Research article · Joint Bone Spine, 2023. Solutions in the top three ranked solutions in 13 NGTs: More research, effective and/or safer new medications/treatments, and joint cartilage restoration (8 groups) 15% votes [43/276]

Hysterectomy and risk of osteoarthritis in women: a nationwide nested case–control study

2026-11-04T23:40:51.898Z

Cohort study · Scand J Rheumatol, 2023. OA, hysterectomy vs no hysterectomy — Hysterectomy vs No hysterectomy: aOR 1.19 (95% CI 1.09-1.30)

Responders to Medial Opening Wedge High Tibial Osteotomy for Knee Osteoarthritis

2026-11-04T23:37:51.551Z

Cohort study · J Rheumatol, 2023. OMERACT-OARSI responders, mean 20.3 (SD 6.2) months post-HTO: Patients meeting responder criteria 406 (78%)

Prevalence of radiographic ankle osteoarthritis in different subgroups of patients referred for ankle radiography

2026-11-04T23:37:28.623Z

Cross-sectional study · Semin Arthritis Rheum, 2022. Prevalence of radiographic ankle OA: Talocrural joint 9.2%

Unsupervised machine-learning algorithms for the identification of clinical phenotypes in the osteoarthritis initiative database

2026-11-04T23:37:28.623Z

Cohort study · Semin Arthritis Rheum, 2022. Patient phenotypes identified: DEC phenotypes 5

Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK).

2026-11-04T23:02:07.938Z

Cohort study · Semin Arthritis Rheum, 2023. Incident RHOA, 2, 5 and 8 years — AD vs No AD: OR 2.46 (95% CI 1.00-6.04); 2 years

Association between baseline meniscal extrusion and long-term incident knee osteoarthritis in two different cohorts

2026-11-04T23:02:07.938Z

Cohort study · Semin Arthritis Rheum, 2023. Incident radiographic knee OA, PROOF, 6.6 years — Meniscal extrusion vs No meniscal extrusion: aOR 2.54 (95% CI 1.34, 4.80); p = 0.004; PAR 21%

The natural history of end-stage knee osteoarthritis: Data from the osteoarthritis initiative

2026-11-04T23:02:07.938Z

Cohort study · Semin Arthritis Rheum, 2022. Knees with moderate-to-severe radiographic OA at the visit before incident esKOA, original definition 62%