Trends in incidence of recorded diagnosis of osteoporosis, osteopenia, and fragility fractures in people aged 50 years and above: retrospective cohort study using UK primary care data
Study context
- Population
- Patients aged 50–99 years registered with a practice participating in THIN, UK, 2000–2018more than 3 million
- Exposure
- Calendar years vs 2000; most vs least deprived areas
- Outcome
- Incidence of first recorded diagnosis of osteoporosis, osteopenia or fragility fracture (incidence rates (IR) per 10,000 person-years; IRR adjusted by age, sex, social deprivation, calendar year and practice effect)
Methodological detailslongitudinal, population-based, UK primary care data (IQVIA Medical Research Database (IMRD)/THIN), Poisson regression
- Longitudinal
- Population-based
- UK primary care data (IMRD/THIN)
- Poisson regression
Main finding
As reported in the abstract
Year-specific adjusted IRR, recorded osteoporosis and fragility fracture, peak year vs 2000
Each group vs 2000Incidence rate ratio (95% CI)
Osteoporosis, women, 2009highest year in women; adjusted
1.44(1.38–1.50)
Osteoporosis, men, 2013-2014highest years in men; adjusted
1.94(1.72–2.18)
Fragility fracture, women, 2012highest year in women; adjusted
1.77(1.69–1.85)
Fragility fracture, men, 2013highest year in men; adjusted
1.64(1.51–1.78)
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| Diagnosis by social deprivation, men (osteoporosis, osteopenia, fragility fracture)Most deprivedvs Least deprivedOsteoporosis, men | 1.45 (1.38–1.53) | |
| Diagnosis by social deprivation, men (osteoporosis, osteopenia, fragility fracture)Most deprivedvs Least deprivedOsteopenia, men | 1.17 (1.09–1.26) | |
| Diagnosis by social deprivation, men (osteoporosis, osteopenia, fragility fracture)Most deprivedvs Least deprivedFragility fracture, men | 1.50 (1.44–1.56) | |
| 0.512Incidence rate ratio (log scale) |
Diagnosis by social deprivation, men (osteoporosis, osteopenia, fragility fracture)
- Smaller differences were seen in women
Original publication
Trends in incidence of recorded diagnosis of osteoporosis, osteopenia, and fragility fractures in people aged 50 years and above: retrospective cohort study using UK primary care data. Osteoporos Int. Published 10 May 2023. doi:10.
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