Autoinflammatory & rare systemic diseases
Treatment and monitoring of synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome: a systematic review
Authors' conclusion
No single currently available treatment option sufficiently addresses all SAPHO-associated symptoms.
Study context
- Population
- Patients with SAPHO syndrome (predominantly European ethnicity) in prospective clinical studies and retrospective case collections with five or more participants28 studies (20 observational, 8 open-label)
- Participants
- 796 patients
- Comparison
- Non-steroidal anti-inflammatory drugs vs Bisphosphonates vs Conventional disease-modifying antirheumatic drugs vs Biological disease-modifying antirheumatic drugs vs TNF inhibitors vs Tofacitinib
- Outcome
- Treatments reported
Methodological detailsPRISMA guidance, PubMed, Scopus and Web of Science
- PRISMA guidance
- PubMed, Scopus and Web of Science
Pooled result
As reported in the abstract
Safety
- Bisphosphonates associated with transient influenza-like symptoms
- Paradoxical skin reactions with TNFi
- No serious adverse events recorded
Original publication
Treatment and monitoring of SAPHO syndrome: a systematic review. RMD Open. Published 26 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →