Trajectories of oral bisphosphonate use after hip fractures: a population-based cohort study
Authors' conclusion
Two-thirds of patients demonstrated good adherence to oral bisphosphonates over 12 months following hip fracture.
Study context
- Population
- Patients aged ≥ 50 years dispensed ≥2 bisphosphonate prescriptions after first hip fracture, Victoria, Australia, 2012–2017
- Participants
- 1,811 patients
- Exposure
- Trajectories of oral bisphosphonate use over 12 months after first hip fracture; factors associated with each trajectory vs persistent adherence
- Outcome
- Twelve-month trajectories of oral bisphosphonate use
- Follow-up
- 12 months
Methodological detailspopulation-based, group-based trajectory modeling, multivariate multinomial logistic regression
- Population-based
- Group-based trajectory modeling
- Multivariate multinomial logistic regression
Main finding
As reported in the abstract
Trajectories of oral bisphosphonate use
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Delayed dispensing: pre-admission bisphosphonate use (both sexes)Delayed dispensingvs Persistent adherencePre-admission bisphosphonate use | 0.28 (0.21–0.39) | |
| Delayed dispensing: age ≥ 85 vs 50-64 years≥ 85 years oldvs 50-64 years old | 0.38 (0.22–0.64) | |
| Early discontinuation: anxiety (males)Early discontinuationvs Persistent adherenceMales with anxiety | 9.80 (2.24–42.9) | |
| Early discontinuation: previous falls (females)Early discontinuationvs Persistent adherenceFemales with previous falls | 1.80 (1.16–2.78) | |
| 0.050.21520Relative risk (log scale) |
Original publication
Trajectories of oral bisphosphonate use after hip fractures: a population-based cohort study. Osteoporos Int. Published 10 January 2024. doi:10.
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