Time trends in newly recorded diagnoses of 19 long term conditions before, during, and after the covid-19 pandemic: population based cohort study in England using OpenSAFELY

BMJPublished Population based cohort study

Authors' conclusion

Since the covid-19 pandemic, there have been fewer diagnoses than expected for conditions such as depression, asthma, COPD, and osteoporosis, in contrast with a rapid increase in diagnoses of chronic kidney disease since 2022. Unadjusted analyses stratified by ethnicity and socioeconomic status suggest differential patterns of recovery, particularly for individuals with dementia.

Study context

Population
Individuals registered with general practices in England contributing data to the OpenSAFELY-TPP platform; primary care and hospital admission data
Participants
29,995,025 individuals
Exposure
Observed vs expected diagnosis rates after onset of covid-19 pandemic
Outcome
Temporal trends in age and sex standardised incident and prevalent diagnosis rates for 19 long term conditions; observed vs expected diagnosis rates after pandemic onset
Follow-up
1 April 2016 to 30 November 2024
Methodological detailsseasonal autoregressive integrated moving-average models, age and sex standardised rates
  • Seasonal autoregressive integrated moving-average models
  • Age and sex standardised rates

Main finding

As reported in the abstract

Cumulative difference in newly recorded diagnoses, observed vs expected · As of November 2024
Depression: fewer diagnoses than expected (95% prediction interval (PI) 703 100 to 766 400)
734 800 (27.7%)
Asthma: fewer diagnoses than expected (95% PI 137 500 to 168 300)
152 900 (16.4%)
Chronic obstructive pulmonary disease (COPD): fewer diagnoses than expected (95% PI 81 400 to 98 900)
90 100 (15.8%)
Psoriasis: fewer diagnoses than expected (95% PI 50 100 to 59 200)
54 700 (17.1%)
Osteoporosis: fewer diagnoses than expected (95% PI 47 100 to 61 100)
54 100 (11.5%)
CKD: increase above expected levels during pandemic recovery period
34.8%
CKD: additional diagnoses (95% PI 333 500 to 384 500)
359 000

Observational data: associations, not effects.

Further findings

Dementia diagnosis rates by ethnicity and socioeconomic status (subgroups)

After initial decrease, rose above pre-pandemic levels for white ethnicity and less deprived areas, but not for other ethnicities and more deprived areas
  • Unadjusted subgroup analyses

Original publication

Time trends in newly recorded diagnoses of 19 long term conditions before, during, and after the covid-19 pandemic: population based cohort study in England using OpenSAFELY. BMJ. Published 21 January 2026. doi:10.1136/bmj-2025-086393

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