Time to pregnancy in women with rheumatoid arthritis who want to conceive treated according to a treat-to-target approach: a comparison of an observational cohort with a historical reference cohort
Authors' conclusion
This study showed that, in women with rheumatoid arthritis treated according to a treat-to-target strategy, time to pregnancy was reduced and was close to that of the general population.
Study context
- Population
- Women with RA who wanted to conceive or were already in their first trimester, Erasmus University Medical Center, The Netherlands
- Participants
- 215 vs 245
- Exposure
- Treat-to-target approach vs historical cohort without this approach
- Preconception Counseling in Active Rheumatoid Arthritis (PreCARA)n = 215
- PARAn = 245reference
- Outcome
- Occurrence of pregnancy and time to pregnancy (first attempt to conceive to first day of last menstrual period before pregnancy)
Methodological detailscomparative, historical controls, single-centre, People with lived experience were involved in the design of both PreCARA and PARA
- Comparative
- Historical controls
- Single-centre
- People with lived experience were involved in the design of both PreCARA and PARA
Main finding
As reported in the abstract
Time to pregnancy
P < 0.0001
Observational data: associations, not effects.
Further findings
Pregnant within 1 year
P < 0.0001
| Outcome | P value |
|---|---|
| Time to pregnancy in PreCARA by clinical remission (subgroup; 131 [61%] of 215 reached remission)PreCARA remission vs PreCARA no remission | P = 0.0054 |
- Time to pregnancy in PreCARA by clinical remission (subgroup; 131 [61%] of 215 reached remission): PreCARA remission median 65 (IQR 19–295) days
- Time to pregnancy in PreCARA by clinical remission (subgroup; 131 [61%] of 215 reached remission): PreCARA no remission median 150 (IQR 49–575) days
Original publication
Time to pregnancy in women with rheumatoid arthritis who want to conceive treated according to a treat-to-target approach: a comparison of an observational cohort with a historical reference cohort. Lancet Rheumatol. Published 26 March 2026. doi:10.
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