The universal presence of poor prognostic factors based on EULAR recommendations: A real-world study in 1164 Chinese rheumatoid arthritis (RA) patients
Authors' conclusion
PPFs are universally present in RA patients.
Study context
- Population
- Chinese RA patients; Poor prognostic factors (PPFs) based on EULAR recommendations
- Participants
- 1,164 patients
- Outcome
- Profile of PPFs based on EULAR recommendations
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
Prevalence of PPFs
- ≥1 PPF
- 97%
- Elevated erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP)
- 746 (64%)
- Positive rheumatoid factor (RF)/anti-citrullinated protein antibody (ACPA)
- 1021 (88%)
- ≥4 swollen joints
- 268 (23%)
- Moderate or high disease activity despite conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) therapy
- 300 (26%)
- Failure of ≥2 csDMARDs
- 30% (224/740)
- Early bone erosions, usually coexisting with other PPFs
- 153/459 (33%)
Observational data: associations, not effects.
Further findings
Correlation of MDA/HDA ≥3 months with other PPFs
- Significantly correlated with elevated ESR/CRP or high swollen joint count (SJC)
- Uncorrelated with RF/ACPA positivity or early erosions
Original publication
The universal presence of poor prognostic factors based on EULAR recommendations: A real-world study in 1164 Chinese RA patients. Joint Bone Spine. Published 6 September 2023. doi:10.
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