Fibromyalgia & musculoskeletal pain

The relationship between balance disorder, brain tractography and volume measurements in fibromyalgia syndrome: a cross-sectional study

Clin Exp RheumatolPublished Cross-sectional study

Authors' conclusion

In conclusion, this study suggests that the balance disorders observed in FM may be a result of lesions and volumetric atrophy occurring in central nervous system (CNS) structures.

Study context

Population
Female individuals aged 18–65 with FM and healthy individuals; brain diffusion tensor imaging (DTI)all female
Participants
30 vs 31
Exposure
FM vs healthy individuals
  • FMn = 30
  • Healthyn = 31reference
Outcome
Cerebellar connection tractography (FA) and volumes of cerebellum VIII-X lobes and vermis on brain MRI
Methodological detailsTractography with DSI Studio; volume analysis with VolBrain
  • Tractography with DSI Studio; volume analysis with VolBrain

Main finding

As reported in the abstract

Fractional anisotropy (FA) lower in FM in tractography of SCP, MCP, ICP and vermis
p<0.05
Cerebellum VIII-X lobes and vermis volume lower in FM
p<0.05

Observational data: associations, not effects.

Original publication

The relationship between balance disorder, brain tractography and volume measurements in fibromyalgia syndrome: a cross-sectional study. Clin Exp Rheumatol. Published 22 June 2026. doi:10.55563/clinexprheumatol/7rvho6

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