The influence of biological DMARDs on aseptic arthroplasty loosening: a retrospective cohort study
Authors' conclusion
Biological DMARDs may reduce the incidence of aseptic loosening after TJA in patients with RA compared with traditional DMARDs.
Study context
- Population
- Patients with RA who underwent THA/TKA at an academic centre, 2002–2015Total joint arthroplasties (TJAs) (103 TKA, 52 THA)
- Participants
- 155 patients
- Exposure
- Biological DMARDs vs traditional DMARDs
- Outcome
- Aseptic loosening, estimated by radiological signs of component loosening (RCL)
Methodological detailssingle-centre, linked to prospective observational RA database, time-dependent Cox regression
- Single-centre
- Linked to prospective observational RA database
- Time-dependent Cox regression
Main finding
As reported in the abstract
Incidence of RCL
Biological DMARDs vs Traditional DMARDs: P = 0.026 · Biological DMARDs vs Traditional DMARDs: P = 0.0447
Observational data: associations, not effects.
Further findings
RCL overall and by arthroplasty site · mean follow-up 69 ± 43 months
- Overall RCL
- 48 (31%)
- RCL after TKA
- 28 (27.2%)
- RCL after THA
- 20 (38.5%)
Original publication
The influence of biological DMARDs on aseptic arthroplasty loosening: a retrospective cohort study. Rheumatology (Oxford). Published 4 July 2023. doi:10.
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