The emerging role of growth differentiation factor 15 as a potential disease biomarker in juvenile dermatomyositis
Authors' conclusion
GDF-15 may serve as a valuable biomarker for assessing disease activity in JDM. It exhibits better sensitivity and specificity than creatine kinase and the levels correlate with various DASs and functional measures.
Study context
- Population
- Children with juvenile myositis (JDM, PM) and healthy controls
- Participants
- 77 / 6 / 22
- Comparison
- JDM vs healthy controls (plasma GDF-15); GDF-15 vs creatine kinase for assessing disease activity
- JDMn = 77
- PMn = 6
- Healthy controlsn = 22reference
- Outcome
- Plasma GDF-15 levels (ELISA)
Main finding
As reported in the abstract
- GDF-15 strongly positively correlated with DAS total, skin and muscle scores and Childhood Myositis Assessment Scale
- GDF-15 differentiated active disease from remission (PGA of muscle score)
- GDF-15 positively correlated with creatine kinase, neopterin and nailfold end row loops
- JDM vs Healthy controls: P < 0.001
Further findings
| Outcome | GDF-15 | Creatine kinase |
|---|---|---|
| Assessing disease activity in JDM (ROC analysis) | ||
| AUC | 0.77 | 0.6369 |
| P | P = 0.001 | P = 0.0738 |
Original publication
The emerging role of growth differentiation factor 15 as a potential disease biomarker in juvenile dermatomyositis. Rheumatology (Oxford). Published 7 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →