Autoinflammatory & rare systemic diseases
The clinical assessment of lung involvement in patients with Still’s disease, results from the multicentre international AIDA Network Still’s Disease Registry
Authors' conclusion
The clinical characteristics of patients with Still's disease and lung involvement were described in the AIDA network. We also provided a clinical profile of patients with parenchymal lung involvement considering its prognostic relevance.
Study context
- Population
- Consecutive patients with Still's disease and lung involvement (pleuritis, parenchymal features, acute respiratory distress syndrome (ARDS) and/or PAH) in the AIDA Network Still's Disease Registry13.3% paediatric
- Participants
- 90 patients
- Exposure
- Parenchymal lung involvement vs other Still's disease patients with lung involvement
- Outcome
- Type of lung involvement
Methodological detailsmulticentre, international, consecutive patients
- Multicentre
- International
- Consecutive patients
Main finding
As reported in the abstract
Pleuritis
72.2%
Parenchymal features
34.4%
ARDS
9.5%
PAH
2.3%
Observational data: associations, not effects.
Further findings
Factors associated with parenchymal lung involvement
- Significantly characterised by sore throat, pericarditis and higher systemic score than others
- IL-1 or IL-6 inhibitors not associated with parenchymal lung involvement
Original publication
The clinical assessment of lung involvement in patients with Still’s disease, results from the multicentre international AIDA Network Still’s Disease Registry. Rheumatology (Oxford). Published 20 January 2025. doi:10.
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