The association of melatonin use and hip fracture: a matched cohort study
Authors' conclusion
In this population-based cohort study, the risk of hip fracture among melatonin initiators was not higher, if not lower, than that among hypnotic benzodiazepines initiators.
Study context
- Population
- Individuals aged 40 years or older without a history of hip fracture or cancer, IQVIA Medical Research Database (IMRD), UK (2000–2018)after PS matching
- Participants
- 9,038 individuals
- Exposure
- Melatonin initiation vs hypnotic benzodiazepines initiation
- Melatoninn = 4,519
- Hypnotic benzodiazepinesn = 4,519reference
- Outcome
- Incident hip fracture
- Follow-up
- Entire
Methodological detailspopulation-based, active comparator
- Population-based
- Active comparator
Main finding
As reported in the abstract
Hip fracture
Melatonin
41
events
Hypnotic benzodiazepines
51
events
Each group vs hypnotic benzodiazepinesAbsolute rate difference, per 1000 person-years (95% CI)
Melatonin
−0.8(−1.9 to 0.3)
Each group vs hypnotic benzodiazepinesMultivariable-adjusted HR (95% CI)
Melatonin
0.78(0.51–1.17)
Observational data: associations, not effects.
Original publication
The association of melatonin use and hip fracture: a matched cohort study. Osteoporos Int. Published 10 April 2023. doi:10.
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