Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.31 95% CI 1.26–1.36Authors' conclusion
We found no meaningful disparities in inpatient care according to the presence of RA; however, those with RA have elevated long-term all-cause mortality post-AMI.
Study context
- Population
- Adults from England and Wales hospitalised with acute myocardial infarction (AMI) between 2005 and 2019, Myocardial Ischaemia National Audit Project registry
- Participants
- 784,091 adults
- Exposure
- Patients with rheumatoid arthritis (RA) vs without RA hospitalised with AMI
- RAn = 6,047
- Outcome
- Long-term all-cause mortality post-AMI (and quality of inpatient AMI care)
- Follow-up
- End of the study period
Methodological detailsregistry-based (MINAP), linked with Office for National Statistics mortality data and hospital episode statistics, Cox regression
- Registry-based (MINAP)
- Linked with Office for National Statistics mortality data and hospital episode statistics
- Cox regression
Main finding
All-cause mortality
Adjusted hazard ratio
1.31
95% CI 1.26–1.36
all P < 0.001
RAvs No RA
aHR 1.31 (95% CI 1.26–1.36); all P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · 1 year | 1.14 (1.07–1.21) | P < 0.001 | |
| All-cause mortality · 5 years | 1.28 (1.23–1.33) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
Cardiovascular mortality · 30 days
- Not significantly different
Cardiovascular mortality · 1 year
- Not significantly different; aHR
- 1.08 (95% CI 1.00-1.17); P = 0.058
Cardiovascular mortality · 5 years
- Significantly different; aHR
- 1.15 (95% CI 1.08-1.23); P < 0.001
Cardiovascular mortality · Study endpoint post-AMI
- Significantly different; aHR
- 1.18 (95% CI 1.11-1.24); P < 0.001
Original publication
Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study. Arthritis Care Res (Hoboken). Published 7 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →