Systemic and local autoantibody responses to extracellular matrix proteins define inflammatory phenotypes across arthropathies
Authors' conclusion
These findings demonstrate that autoantibodies against PRG4 and COMP are present across arthropathies with distinct patterns reflecting different pathogenic mechanisms.
Study context
- Population
- Healthy controls and patients with OA, RA or JIA
- Exposure
- OA, RA and JIA vs healthy controls
- Outcome
- Systemic and local (SF) levels of PRG4 and COMP and their autoantibodies
Methodological detailsELISA of serum and synovial fluid
- ELISA of serum and synovial fluid
Main finding
As reported in the abstract
PRG4, COMP and their autoantibodies in serum and SF
- Serum PRG4 significantly decreased in RA vs controls and OA; elevated in JIA
- Serum cartilage oligomeric matrix protein (COMP) significantly elevated in OA and JIA vs controls and RA
- SF PRG4 decreased in OA vs all other groups; SF COMP highest in OA and controls
- Serum anti-PRG4 significantly elevated in all disease groups vs controls; RA and JIA also increased in SF
- Anti-COMP significantly increased in RA and JIA serum and elevated in all disease groups in SF vs controls
- Positive correlation between PRG4 protein and anti-PRG4 antibodies specifically in OA SF
Observational data: associations, not effects.
Original publication
Systemic and local autoantibody responses to extracellular matrix proteins define inflammatory phenotypes across arthropathies. Rheumatology (Oxford). Published 9 September 2026. doi:10.
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