Across rheumatic diseases

Systematic screening for multimorbidities in patients with inflammatory rheumatic diseases enhanced preventive medication use and reduced hospitalisations: an exposed-non-exposed study

RMD OpenPublished Exposed-non-exposed cohort study

Main finding · Meeting the PE (multivariate analysis)Result — go to the resultAdjusted odds ratio 1.6 CI 1.2–2.2

Authors' conclusion

Systematic multimorbidity screening in patients with IRD boosted preventive medication use and reduced hospital admissions

Study context

Population
Patients with chronic inflammatory rheumatic diseases (IRD) in the French national health database
Participants
286 vs 858
Exposure
Systematic multimorbidity screening programme vs no screening
  • Exposedn = 286
  • Controlsn = 858reference
Outcome
Composite score of dispensation of multimorbidity-preventing drugs:
  • Vaccines
  • Lipid-lowering agents
  • Antiosteoporotic medications
  • Antiplatelet drugs
Follow-up
Year following the index date
Methodological detailsFrench national health database, matched controls, multivariate analysis, propensity score matching
  • French national health database
  • Matched controls
  • Multivariate analysis
  • Propensity score matching

Main finding

Meeting the PE (multivariate analysis)

Adjusted odds ratio

1.6

CI 1.2–2.2

P < 0.01

Exposedvs Controls
aOR 1.6 (CI 1.2–2.2); P < 0.01

As reported in the abstract

Observational data: associations, not effects.

Further findings

Meeting the PE (propensity score matched analysis) · year following the index date

OR 1.5 · P = 0.015

Emergency admission and hospitalisations for fracture, cardiovascular events or infection · propensity score matched

OR 0.42 · P < 0.01

Severe infections · propensity score matched

P = 0.03

  • Meeting the primary endpoint (PE) (propensity score matched analysis): propensity score matched: 281 exposed and 281 controls

Meeting the PE (propensity score matched analysis) · year following the index date

Increased utilisation of vaccines, cholesterol-lowering drugs and antiosteoporotic medications

Original publication

Systematic screening for multimorbidities in patients with inflammatory rheumatic diseases enhanced preventive medication use and reduced hospitalisations: an exposed-non-exposed study. RMD Open. Published 2 October 2024. doi:10.1136/rmdopen-2024-004490

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