Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis
Authors' conclusion
Socioeconomic deprivation is associated with reduced response to TNFi.
Study context
- Population
- Individuals with RA commencing their first TNF inhibitor (TNFi) in the British Society for Rheumatology Biologics Register for RA (BSRBR-RA) and Biologics in RA Genetics and Genomics Study Syndicate (BRAGGSS) cohortsBSRBR-RA
- Participants
- 16,085 individuals
- Exposure
- 20% most deprived and middle 40% vs 40% least deprived
- Outcome
- DAS28-derived outcomes
- Follow-up
- 6 months (BSRBR-RA) and 3 months (BRAGGSS)
Methodological detailstwo cohorts (BSRBR-RA and BRAGGSS), regression models, Cox models
- Two cohorts (BSRBR-RA and BRAGGSS)
- Regression models
- Cox models
Main finding
As reported in the abstract
6-month DAS28 (BSRBR-RA) · 6 months
Most deprived vs Least deprivedDifference, unit (95% CI)
Unadjusted
0.3(0.22–0.37)
Most deprived vs Least deprivedOdds ratio (95% CI)
Low disease activity; unadjusted
0.76(0.68–0.84)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause TNFi discontinuation (BSRBR-RA)Most deprivedvs Least deprivedDriven by ineffectiveness rather than adverse events · Adjusted estimates were generally attenuated | 1.18 (1.12–1.25) | |
| 0.512Hazard ratio (log scale) |
DAS28 at 3 months (BRAGGSS), most vs least deprived
- Results similar to BSRBR-RA for 3-month DAS28
- β = 0.23; 95% CI 0.11, 0.36
- Unadjusted
Low disease activity at 3 months (BRAGGSS), most vs least deprived
- Results similar to BSRBR-RA for 3-month low disease activity
- OR 0.77; 95% CI 0.63, 0.94
- Unadjusted
Original publication
Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis. Rheumatology (Oxford). Published 2 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →