Similar gout flare incidence rates when using once- or twice-daily 0.5 mg colchicine prophylaxis after the start of xanthine oxidase inhibitors
Authors' conclusion
Colchicine prophylaxis 0.5 mg twice daily was not superior to colchicine once daily regarding flare prophylaxis after starting an XOI.
Study context
- Population
- Gout patients starting xanthine oxidase inhibitors (XOIs) (allopurinol in 99.7%) with colchicine prophylaxis, three rheumatology centres in the Netherlands
- Participants
- 808 patients
- Exposure
- Colchicine 0.5 mg twice daily vs once daily as prophylaxis after starting XOIs
- Twice-dailyn = 192
- Once-dailyn = 616reference
- Outcome
- Gout flare incidence density
- Follow-up
- First 6 months after starting XOIs
Methodological detailsmulticentre, Poisson regression, adjusted for confounders
- Multicentre
- Poisson regression, adjusted for confounders
Main finding
Gout flares, incidence density · first 6 months
Incidence rate ratio
0.93
95% CI 0.80–1.09
By group
Twice-dailyvs Once-daily
IRR 0.93 (95% CI 0.80–1.09)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Serum urate target (<0.36 mmol/L) reached · within 6 months
difference (%) −8.8 (1.1% to −18.7%)
Original publication
Similar gout flare incidence rates when using once- or twice-daily 0.5 mg colchicine prophylaxis after the start of xanthine oxidase inhibitors. Scand J Rheumatol. Published 11 August 2025. doi:10.
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