Significant decrease of osteoporosis and osteoporotic fractures in rheumatoid arthritis within a period of 24 years: experiences of a single centre
Authors' conclusion
Our study showed a significant decline in osteoporosis and osteoporotic fractures in RA for 24 years.
Study context
- Population
- Rheumatoid arthritis (RA) patients at first osteological assessment with bone mineral density (BMD) measurement, 1996–2019, single clinic
- Participants
- 547 vs 539
- Exposure
- Cohort 2 vs cohort 1
- Cohort 2n = 547
- Cohort 1n = 539reference
- Outcome
- Frequency of osteoporosis and osteoporotic fractures
Methodological detailssingle-centre, linear regression analysis
- Single-centre
- Linear regression analysis
Main finding
As reported in the abstract
Prevalence of osteoporosis
P < 0.001
Observational data: associations, not effects.
Further findings
Osteoporotic peripheral fractures
P < 0.001
Vertebral fractures
P = 0.011
Treatment with biologicals
P < 0.001
- GC use · significantly less common in cohort 2
- P = 0.005
BMD under biologicals (RA disease duration >2 years)
- BMD significantly higher under treatment with biologicals
- P < 0.001
- Despite increased cumulative GC dosages
- P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Significant decrease of osteoporosis and osteoporotic fractures in rheumatoid arthritis within a period of 24 years: experiences of a single centre. RMD Open. Published 20 August 2024. doi:10.
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