Side-to-side differences in hip bone mineral density and associated morphological factors
Authors' conclusion
A considerable proportion of older adults exhibited clinically relevant side-to-side differences in hip BMD.
Study context
- Population
- Adults (median age 75 years) without a history of lower extremity disorders
- Participants
- 82 adults
- Outcome
- Side-to-side percentage difference in total hip BMD (QCT)
Methodological detailsQuantitative computed tomography (QCT)-based, deep learning bone mineral density (BMD) calculation, multivariate analysis
- QCT-based
- Deep learning BMD calculation
- Multivariate analysis
Main finding
As reported in the abstract
Side-to-side difference in total hip BMD (QCT)
Median side-to-side BMD difference (IQR 1.6%-5.8%)
3.0%
Participants with BMD difference exceeding 5%
26%
Increase in proportion with T-scores ≤ - 2.5 when bilateral data used
2%
Observational data: associations, not effects.
Further findings
Proportion with T-scores ≤ - 2.5 using bilateral data
- Increase in proportion with T-scores ≤ - 2.5 when bilateral data were used
- 2%
Morphological factors associated with BMD differences (multivariate analysis)
- Greater differences in gluteal muscle volume and femoral anteversion independently associated with larger BMD differences
- Side with smaller gluteal muscle volume and greater femoral anteversion exhibited lower BMD
Original publication
Side-to-side differences in hip bone mineral density and associated morphological factors. Osteoporos Int. Published 22 July 2026. doi:10.
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