Vasculitis & polymyalgia rheumatica
Serum immunoreactivity to neurofilament-medium shows high sensitivity and specificity in patients with Behçet disease
Authors' conclusion
These findings reveal the ubiquitous presence of NF-M immunoreactivity, reportedly cross-reacting with bacterial heat shock protein 65, in BD sera.
Study context
- Population
- Patients with behçet disease (BD), systemic lupus erythematosus (SLE), multiple sclerosis (MS), psoriatic arthritis (PsA) and non-Behçet uveitis, and healthy donors76 patients · 22 healthy donors
- Participants
- 98 patients
- Comparison
- Serum NF-M immunoreactivity in BD vs SLE, MS, PsA, non-Behçet uveitis and healthy donors
- BDn = 33
- MSn = 16
- SLEn = 15
- PsAn = 9
- Non-Behçet uveitis (NBU)n = 3
- Healthy donorsn = 22reference
- Outcome
- Sensitivity and specificity of serum NF-M immunoreactivity
Methodological detailsindependent replication cohort, immunolabelling of mouse brain tissue sections with confocal microscopy
- Independent replication cohort
- Immunolabelling of mouse brain tissue sections with confocal microscopy
Performance
As reported in the abstract
Fine filamentous staining pattern consistent with NF-M immunolabelling in axons
BD
97%
32 of 33
Further findings
Other staining patterns
- MS sera: thick filamentous staining attributed to oligodendrocytes and myelin-forming processes
- SLE sera: intense labelling of all cell nuclei, consistent with immunoreactivity against nuclear antigens
Original publication
Serum immunoreactivity to neurofilament-medium shows high sensitivity and specificity in patients with Behçet disease. RMD Open. Published 30 May 2025. doi:10.
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