Risk factors of mortality in patients with rheumatoid arthritis-associated interstitial lung disease: a single-centre prospective cohort study
Authors' conclusion
Patients with RA-ILD have an elevated risk of mortality compared with those without ILD. Infection-related deaths are the main causes of mortality in this population. High RA activity, low DLCO, and the UIP pattern are significantly associated with the mortality in patients with RA-ILD.
Study context
- Population
- Korean rheumatoid arthritis (RA) patients with a chest CT scan at an academic referral hospital in Korea
- Participants
- 615 patients
- Exposure
- RA-ILD vs RA without interstitial lung disease (ILD)
- RA-ILDn = 200
- RA-nonILDn = 415reference
- Outcome
- Mortality and its risk factors in RA-ILD
Methodological detailssingle-centre, Cox proportional hazard regression with Firth's penalised likelihood method
- Single-centre
- Cox proportional hazard regression with Firth's penalised likelihood method
Main finding
As reported in the abstract
Mortality
| Group | Value | Person-years |
|---|---|---|
| RA-ILD | 2.78/100 person-years (PYs) | 540.1 |
| RA-nonILD | 0 events | 1669.9 |
Value
RA-ILD2.78/100 PYs
RA-nonILD0 events
Person-years
RA-ILD540.1
RA-nonILD1669.9
- High RA activity, risk factor for mortality in RA-ILD
- 1.87, CI 1.16-3.10 (adjusted HR, CI level not stated)
- Baseline DLCO < 60%, risk factor for mortality in RA-ILD
- adjusted HR 4.88, 1.11-45.94 (95% CI)
- Usual interstitial pneumonia (UIP) pattern, risk factor for mortality in RA-ILD
- adjusted HR 5.13, 1.00-57.36 (95% CI)
Observational data: associations, not effects.
Further findings
Causes of death in RA-ILD
- Infection
- 9
- Lung cancer
- 5
- ILD aggravation
- 1
Original publication
Risk factors of mortality in patients with rheumatoid arthritis-associated interstitial lung disease: a single-centre prospective cohort study. Arthritis Res Ther. Published 19 July 2024. doi:10.
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