Systemic sclerosis & Raynaud's
Psychometric Evaluation of the Scleroderma Skin Questionnaire: A Novel Patient-Reported Outcome for Skin Disease in Patients With Systemic Sclerosis
Authors' conclusion
SSQ demonstrated high reliability and moderate correlation with mRSS and legacy PROs.
Study context
- Population
- Adults with systemic sclerosis (SSc) enrolled in the SSc Collaborative National Quality and Efficacy Registry (CONQUER) (mean age 52.7; 83% female)
- Participants
- 799 adults
- Outcome
- Psychometric properties of the SSQ: internal consistency (Cronbach α, McDonald ωt) and criterion, convergent and divergent validity vs mRSS, PGA, Scleroderma HAQ, PROMIS-29 and patient global assessment
Methodological detailsregistry-based (CONQUER)
- Registry-based (CONQUER)
Performance
As reported in the abstract
Internal consistency and validity of the SSQ
- Cronbach α
- 0.90
- McDonald ωt
- 0.92
- Correlation with modified Rodnan skin score (mRSS) (r)
- 0.56
- Correlation with mRSS, diffuse cutaneous subtype (r)
- 0.54
- Correlation with mRSS, limited cutaneous subtype (r; all P < 0.05)
- 0.24
- Correlation with Patient-Reported Outcomes Measurement Information System (PROMIS-29) physical function (r)
- −0.50
- Correlation with PROMIS-29 pain interference (r)
- 0.61
- Correlation with HAQ score (r)
- 0.63
- Correlation with HAQ severity subscale (r)
- 0.62
- Correlation with physician global assessment (PGA) SSc activity score (r; all P < 0.05)
- 0.48
Further findings
Scleroderma Skin Questionnaire (SSQ) 6-Month vs 6-month change in mRSS (weak correlation)
- Correlation (r; P < 0.05)
- 0.26
Original publication
Psychometric Evaluation of the Scleroderma Skin Questionnaire: A Novel Patient-Reported Outcome for Skin Disease in Patients With Systemic Sclerosis. J Rheumatol. Published 15 January 2025. doi:10.
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