Prognostic factors for interstitial lung disease progression in rheumatoid arthritis: May methotrexate protect against progression?
Authors' conclusion
Our findings indicate a negative association between methotrexate use and ILD progression.
Study context
- Population
- RA-ILD patients with at least one follow-up lung computed tomography (CT)
- Participants
- 104 patients215 lung CT scans
- Exposure
- RA-ILD with vs without radiographic progression on lung CT
- Progressionn = 43
- Outcome
- Radiographic ILD progression on lung CT and its associated factors
Methodological detailsretrospective observational, CT scans re-evaluated by three radiologists, multivariate logistic regression adjusted for interstitial lung disease (ILD) disease duration
- Retrospective observational
- CT scans re-evaluated by three radiologists
- Multivariate logistic regression adjusted for ILD disease duration
Main finding
As reported in the abstract
Radiographic progression
Progression
41.3%
43
Observational data: associations, not effects.
Further findings
Univariate factors more common with progression
- Male sex, ILD findings on last X-ray, age at ILD diagnosis > 50 years and ground-glass opacity on CT more common in the progression group
Original publication
Prognostic factors for interstitial lung disease progression in rheumatoid arthritis: May methotrexate protect against progression? Scand J Rheumatol. Published 25 July 2024. doi:10.
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