Prevalence and risk factors of non-tuberculous mycobacterial pulmonary isolates and infection in interstitial lung disease associated with systemic autoimmune disease
Authors' conclusion
In patients with SAD-ILD, the NTM-PI and NTM-LD prevalence rates were 20.9% and 8.1%, respectively. COPD and CKD were independent risk factors of both NTM-PI and NTM-LD. Previous use of biological agents was associated with NTM-PI.
Study context
- Population
- Patients with systemic autoimmune disease (SAD) and concurrent interstitial lung disease (ILD) with sputum collected for non-tuberculous mycobacterial (NTM) culture, tertiary referral hospital, 2003–2018
- Participants
- 204 / 54 / 33 / 21
- Exposure
- NTM pulmonary isolates (NTM-PI) vs NTM-negative patients with SAD-ILD
- NTM-negativen = 204reference
- NTM-PIn = 54
- NTM 1+n = 33
- NTM-LDn = 21
- Outcome
- Prevalence and risk factors of NTM-PI (≥1 positive culture) and NTM-LD (≥2 positive cultures)
Methodological detailssingle-centre (tertiary referral hospital), multivariable analysis
- Single-centre (tertiary referral hospital)
- Multivariable analysis
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Risk factors for NTM-PI (multivariable)
- Chronic kidney disease (CKD), aOR
- 3.10 [1.53, 6.29] (CI as printed)
- Chronic obstructive pulmonary disease (COPD), aOR
- 2.59 [1.16, 5.78] (CI as printed)
Risk factors for NTM-LD (multivariable)
- CKD, aOR
- 2.79 [1.00, 7.76] (CI as printed)
- COPD, aOR
- 3.70 [1.23, 10.72] (CI as printed)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prevalence and risk factors of non-tuberculous mycobacterial pulmonary isolates and infection in interstitial lung disease associated with systemic autoimmune disease. Clin Exp Rheumatol. Published 10 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →