Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (biomechanical computed tomography (BCT))
Authors' conclusion
Opportunistic BCT in male veterans provides an additional avenue to identify patients who are at high risk of fractures.
Study context
- Population
- Male veterans age ≥ 65 with abdominal/pelvic CTs performed in 2017–2019
- Participants
- 577 randomly selected men
- Exposure
- Age 65-74 vs Age 75-84 vs Age ≥ 85
- Outcome
- Prevalence of osteoporosis by BCT, defined by hip BMD (T-score ≤ - 2.5) or fragile bone strength (≤ 3500 N)
Methodological detailsopportunistic BCT of existing hip-containing CT scans, random selection, multivariate logistic regression
- Opportunistic BCT of existing hip-containing CT scans
- Random selection
- Multivariate logistic regression
Main finding
As reported in the abstract
Prevalence of osteoporosis by BCT
- Estimated overall prevalence, men age ≥ 65
- 18.3%
- Men with osteoporosis
- 108/577
Observational data: associations, not effects.
Further findings
Factors associated with osteoporosis by BCT
| OR (95% CI) | ||
|---|---|---|
| End stage renal disease | 7.4 (2.3–23.9) | |
| COPD | 2.2 (1.2–4.0) | |
| High-dose inhaled corticosteroid use | 3.7 (1.2–11.8) | |
| 0.050.21520Odds ratio (log scale) |
- Factors associated with osteoporosis by BCT: multivariate logistic regression adjusted for age, BMI, race, and CT location
Prior DXA among men with osteoporosis
- Prior DXA
- 38.0% (41/108)
- Received osteoporosis pharmacotherapy
- 18.6% (7/108)
FRAX hip fracture risk ≥ 3% vs fragile bone strength
- Elevated hip fracture risk by FRAX (≥ 3%) did not fully capture those with fragile bone strength
Original publication
Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT). Osteoporos Int. Published 29 December 2022. doi:10.
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