Vasculitis & polymyalgia rheumatica
PD-1 on CD8+T cells are low in Behçet's disease and is not normalised with type-I interferon
Authors' conclusion
The decreased PD-1 expression on CD8+T cells, along with the decreased PD-1, TIM-3 and TIGIT responses of CD8+T cells upon IFN-I stimulation, demonstrated an altered immune response in BD.
Study context
- Population
- Patients with Behçet's disease (BD) and age- and sex-matched healthy and diseased controls
- Participants
- 37 / 24 / 29
- Comparison
- BD vs healthy and diseased controls
- BDn = 37
- Healthy controlsn = 24reference
- Diseased controlsn = 29reference
- Outcome
- PD-1 on CD8+T cells and its response to IFN-I
Methodological detailsage- and sex-matched controls, in vitro stimulation
- Age- and sex-matched controls
- In vitro stimulation
Main finding
As reported in the abstract
- PD-1 on CD8+T cells with potentially regulatory functions significantly lower in BD than in controls, regardless of disease activity
- CD3 stimulation of PBMCs induced PD-1 expression in all groups
- Increase of PD-1 on CD8+T cells with added interferon seen in controls, not in BD
- Responsive increase of TIM-3 and TIGIT seen in controls, not in BD
Original publication
PD-1 on CD8+T cells are low in Behçet's disease and is not normalised with type-I interferon. Clin Exp Rheumatol. Published 3 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →